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M94A2973.TXT
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1994-10-25
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Document 2973
DOCN M94A2973
TI Oral hairy leukoplakia (OHL): topical use of trichloroacetic and
glycolic acids--results.
DT 9412
AU Nishio CE; Petri V; Narahashi E; Department of Dermatology, Escola
Paulista de Medicina, SP,; Brazil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):182 (abstract no. PB0153). Unique
Identifier : AIDSLINE ICA10/94369602
AB OBJECTIVE: to investigate perspectives of control of oral hairy
leukoplakia (OHL) of HIV-seropositive patients. METHODS: 10
HIV-seropositive individuals were submitted to trichloroacetic acid
(TCA) 40% and 10 other (HIV-seropositive) to glycolic acid (GA) 30%,
topically. RESULTS: all patients reported good results if using TCA or
GA regularly (2 to 3 times a week for TCA, 1 to 2 times a day for GA).
All patients referred recurrence of OHL if treatment is interrupted. No
significant discomfort was related in both cases. TCA seemed to be more
quickly effective (24-48 hours after topical use), in spite of its
relatively non-aesthetics aspect in the first 12-24 hours after
administration (see figure); GA was apparently effective after 10 to 21
days of regular treatment. CONCLUSIONS: TCA and/or GA, both effective
products used against some cutaneous viral and non-viral diseases
(papillomavirus, molluscum contagiosum and queratotic disorders of the
skin), can be used easily, without significant discomfort and relatively
good results, during the time of persistence of OHL (see figures).
DE Administration, Topical Comparative Study Drug Administration Schedule
Glycolates/*ADMINISTRATION & DOSAGE Human HIV Seropositivity/*DRUG
THERAPY Leukoplakia, Hairy/*DRUG THERAPY Recurrence Treatment Outcome
Trichloroacetic Acid/*ADMINISTRATION & DOSAGE MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).